Ontology highlight
ABSTRACT:
SUBMITTER: Lu S
PROVIDER: S-EPMC8494060 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Lu Shuiyu S Haskali Mohammad B MB Ruley Kevin M KM Dreyfus Nicolas J-F NJ DuBois Susan L SL Paul Soumen S Liow Jeih-San JS Morse Cheryl L CL Kowalski Aneta A Gladding Robert L RL Gilmore Jeremy J Mogg Adrian J AJ Morin S Michelle SM Lindsay-Scott Peter J PJ Ruble J Craig JC Kant Nancy A NA Shcherbinin Sergey S Barth Vanessa N VN Johnson Michael P MP Cuadrado Maria M Jambrina Enrique E Mannes Andrew J AJ Nuthall Hugh N HN Zoghbi Sami S SS Jesudason Cynthia D CD Innis Robert B RB Pike Victor W VW
Science translational medicine 20200501 543
We aimed to develop effective radioligands for quantifying brain <i>O</i>-linked-β-<i>N</i>-acetyl-glucosamine (<i>O</i>-GlcNAc) hydrolase (OGA) using positron emission tomography in living subjects as tools for evaluating drug target engagement. Posttranslational modifications of tau, a biomarker of Alzheimer's disease, by <i>O</i>-GlcNAc through the enzyme pair OGA and <i>O</i>-GlcNAc transferase (OGT) are inversely related to the amounts of its insoluble hyperphosphorylated form. Increase in ...[more]