Gene-Based Association Mapping for Dental Caries in The GENEVA Consortium.

ABSTRACT:

Objective

Dental caries is a multifactorial disease with high prevalence in both children and adults. Recent genome-wide association studies (GWASs) have revealed that genetic factors play an important role in caries incidence. However, existing methods are not sufficient to identify caries-associated genes, due to the complex correlation structure of caries GWAS data, and lack of appropriate summarization at the gene level. This paper attempts to address that by analyzing data from the Gene, Environment Association Studies (GENEVA) consortium.

Methods

We investigated gene-based genetic associations for dental caries based on genome-wide data derived from the GENEVA database, with adjustment to covariates, linkage disequilibrium among single-nucleotide polymorphisms, and fam

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8494074 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature