Facilitating functionalization of benzene-1,3,5-tricarboxamides by switching amide connectivity.

ABSTRACT: Synthetic water-compatible supramolecular polymers based on benzene-1,3,5-tricarboxamides (BTAs) have attracted a lot of interest in recent years, as they are uniquely suited to generate functional multicomponent biomaterials. Their morphologies and intrinsic dynamic behaviour mimic fibrous structures found in nature. Moreover, their modularity allows control of the density of functionalities presented on the surface of the fibres when using functionalized BTA monomers. However, such moieties generally comprise a functionality on only one of three side chains, resulting in lengthy synthetic protocols and limited yields. In this work, we avert the need for desymmetrization of the core by starting from commercially available 5-aminoisophthalic acid. This approach eliminates the statistical r

SUBMITTER: Schoenmakers SMC 

PROVIDER: S-EPMC8494077 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature