Re-evaluation of population-level protection conferred by a rotavirus vaccine using the 'fried-egg' approach in a rural setting in Bangladesh.

ABSTRACT:

Background

Vaccine herd protection assessed in a cluster-randomized trial (CRT) may be masked by disease transmission into the cluster from outside. However, herd effects can be unmasked using a 'fried-egg' approach whereby the analysis, restricted to the innermost households of clusters, 'yolk', creates an insulating 'egg-white' periphery. This approach has been demonstrated to unmask vaccine herd protection in reanalyses of cholera and typhoid vaccine CRTs. We applied this approach to an earlier CRT in Bangladesh of rotavirus vaccine (RV) whose overall analysis had failed to detect herd protection. Herein we present the results of this analysis.

Methods

In the study area, infants in 142 villages were randomized to receive two doses of RV with routine EPI vaccines (RV villa

SUBMITTER: Aziz AB 

PROVIDER: S-EPMC8494114 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature