Mapping the regulatory landscape of auditory hair cells from single-cell multi-omics data.

ABSTRACT: Auditory hair cells transduce sound to the brain, and in mammals, these cells reside together with supporting cells in the sensory epithelium of the cochlea, called the organ of Corti. To establish the organ's delicate function during development and differentiation, spatiotemporal gene expression is strictly controlled by chromatin accessibility and cell type-specific transcription factors, jointly representing the regulatory landscape. Bulk sequencing technology and cellular heterogeneity obscured investigations on the interplay between transcription factors and chromatin accessibility in inner ear development. To study the formation of the regulatory landscape in hair cells, we collected single-cell chromatin accessibility profiles accompanied by single-cell RNA data from genetically la

SUBMITTER: Wang S 

PROVIDER: S-EPMC8494220 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature