A single-cell atlas reveals unanticipated cell type complexity in Drosophila ovaries.

ABSTRACT: Organ function relies on the spatial organization and functional coordination of numerous cell types. The Drosophila ovary is a widely used model system to study the cellular activities underlying organ function, including stem cell regulation, cell signaling and epithelial morphogenesis. However, the relative paucity of cell type-specific reagents hinders investigation of molecular functions at the appropriate cellular resolution. Here, we used single-cell RNA sequencing to characterize all cell types of the stem cell compartment and early follicles of the Drosophila ovary. We computed transcriptional signatures and identified specific markers for nine states of germ cell differentiation and 23 somatic cell types and subtypes. We uncovered an unanticipated diversity of escor

SUBMITTER: Slaidina M 

PROVIDER: S-EPMC8494228 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature