Locus-specific analysis of Transposable Elements during the progression of ALS in the SOD1G93A mouse model.

ABSTRACT: Transposable Elements (TEs) are ubiquitous genetic elements with the ability to move within a genome. TEs contribute to a large fraction of the repetitive elements of a genome, and because of their nature, they are not routinely analyzed in RNA-Seq gene expression studies. Amyotrophic Lateral Sclerosis (ALS) is a lethal neurodegenerative disease, and a well-accepted model for its study is the mouse harboring the human SOD1G93A mutant. In this model, landmark stages of the disease can be recapitulated at specific time points, making possible to understand changes in gene expression across time. While there are several works reporting TE activity in ALS models, they have not explored their activity through the disease progression. Moreover, they have done it at the expense of losing their lo

SUBMITTER: Valdebenito-Maturana B 

PROVIDER: S-EPMC8494334 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature