Association of vaginal bacterial communities and reproductive outcomes with prophylactic antibiotic exposure in a subfertile population undergoing in vitro fertilization: a prospective exploratory study.

ABSTRACT:

Objective

To determine whether prophylactic azithromycin is associated with the vaginal bacterial microbiome and clinical outcomes in subfertile women undergoing in vitro fertilization (IVF).

Design

Prospective exploratory cohort study.

Setting

Single academic fertility center.

Patients

Subfertile women aged 18-43 years undergoing their first IVF cycle and fresh embryo transfer.

Intervention

Primary exposure to prophylactic azithromycin (1 g orally) once at baseline.

Main outcome measures

The primary outcome was the effect of azithromycin on the vaginal microbiome compared with a no-azithromycin group at 3 time points throughout the IVF cycle (baseline, retrieval, and embryo transfer). The secondary outcomes were associations of vaginal bacterial

SUBMITTER: Eskew AM 

PROVIDER: S-EPMC8494411 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature