Targeting neurons in the tumor microenvironment with bupivacaine nanoparticles reduces breast cancer progression and metastases.
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ABSTRACT:
SUBMITTER: Kaduri M
PROVIDER: S-EPMC8494443 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Publications
Targeting neurons in the tumor microenvironment with bupivacaine nanoparticles reduces breast cancer progression and metastases.
Kaduri Maya M Sela Mor M Kagan Shaked S Poley Maria M Abumanhal-Masarweh Hanan H Mora-Raimundo Patricia P Ouro Alberto A Dahan Nitsan N Hershkovitz Dov D Shklover Jeny J Shainsky-Roitman Janna J Buganim Yosef Y Schroeder Avi A
Science advances 20211006 41
Neurons within the tumor microenvironment promote cancer progression; thus, their local targeting has potential clinical benefits. We designed PEGylated lipid nanoparticles loaded with a non-opioid analgesic, bupivacaine, to target neurons within breast cancer tumors and suppress nerve-to-cancer cross-talk. In vitro, 100-nm nanoparticles were taken up readily by primary neurons, trafficking from the neuronal body and along the axons. We demonstrate that signaling between triple-negative breast c ...[more]
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