A multimodal cell census and atlas of the mammalian primary motor cortex.

ABSTRACT: Here we report the generation of a multimodal cell census and atlas of the mammalian primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network (BICCN). This was achieved by coordinated large-scale analyses of single-cell transcriptomes, chromatin accessibility, DNA methylomes, spatially resolved single-cell transcriptomes, morphological and electrophysiological properties and cellular resolution input-output mapping, integrated through cross-modal computational analysis. Our results advance the collective knowledge and understanding of brain cell-type organization^1-5. First, our study reveals a unified molecular genetic landscape of cortical cell types that integrates their transcriptome, open chromatin and DNA methylation maps. Second, cross-specie

SUBMITTER: BRAIN Initiative Cell Census Network (BICCN) 

PROVIDER: S-EPMC8494634 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature