A transcriptomic atlas of mouse cerebellar cortex comprehensively defines cell types.

ABSTRACT: The cerebellar cortex is a well-studied brain structure with diverse roles in motor learning, coordination, cognition and autonomic regulation. However,  a complete inventory of cerebellar cell types is currently lacking. Here, using recent advances in high-throughput transcriptional profiling^1-3, we molecularly define cell types across individual lobules of the adult mouse cerebellum. Purkinje neurons showed considerable regional specialization, with the greatest diversity occurring in the posterior lobules. For several types of cerebellar interneuron, the molecular variation within each type was more continuous, rather than discrete. In particular, for the unipolar brush cells-an interneuron population previously subdivided into discrete populations-the continuous variation in

SUBMITTER: Kozareva V 

PROVIDER: S-EPMC8494635 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature