An atlas of gene regulatory elements in adult mouse cerebrum.

ABSTRACT: The mammalian cerebrum performs high-level sensory perception, motor control and cognitive functions through highly specialized cortical and subcortical structures¹. Recent surveys of mouse and human brains with single-cell transcriptomics^2-6 and high-throughput imaging technologies^7,8 have uncovered hundreds of neural cell types distributed in different brain regions, but the transcriptional regulatory programs that are responsible for the unique identity and function of each cell type remain unknown. Here we probe the accessible chromatin in more than 800,000 individual nuclei from 45 regions that span the adult mouse isocortex, olfactory bulb, hippocampus and cerebral nuclei, and use the resulting data to map the state of 491,818 candidate cis-regulatory

SUBMITTER: Li YE 

PROVIDER: S-EPMC8494637 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature