A proteomics sample metadata representation for multiomics integration and big data analysis.

ABSTRACT: The amount of public proteomics data is rapidly increasing but there is no standardized format to describe the sample metadata and their relationship with the dataset files in a way that fully supports their understanding or reanalysis. Here we propose to develop the transcriptomics data format MAGE-TAB into a standard representation for proteomics sample metadata. We implement MAGE-TAB-Proteomics in a crowdsourcing project to manually curate over 200 public datasets. We also describe tools and libraries to validate and submit sample metadata-related information to the PRIDE repository. We expect that these developments will improve the reproducibility and facilitate the reanalysis and integration of public proteomics datasets.

SUBMITTER: Dai C 

PROVIDER: S-EPMC8494749 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature