Mapping thalamocortical functional connectivity with large-scale brain networks in patients with first-episode psychosis.

ABSTRACT: Abnormal thalamocortical networks involving specific thalamic nuclei have been implicated in schizophrenia pathophysiology. While comparable topography of anatomical and functional connectivity abnormalities has been reported in patients across illness stages, previous functional studies have been confined to anatomical pathways of thalamocortical networks. To address this issue, we incorporated large-scale brain network dynamics into examining thalamocortical functional connectivity. Forty patients with first-episode psychosis and forty healthy controls underwent T1-weighted and resting-state functional magnetic resonance imaging. Independent component analysis of voxelwise thalamic functional connectivity maps parcellated the cortex into thalamus-related networks, and thalamic subdivisio

SUBMITTER: Kwak YB 

PROVIDER: S-EPMC8494789 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature