Cardiac tyrosine hydroxylase activation and MB-COMT in dyskinetic monkeys.

ABSTRACT: The impact of age-associated disorders is increasing as the life expectancy of the population increments. Cardiovascular diseases and neurodegenerative disorders, such as Parkinson's disease, have the highest social and economic burden and increasing evidence show interrelations between them. Particularly, dysfunction of the cardiovascular nervous system is part of the dysautonomic symptoms of Parkinson's disease, although more studies are needed to elucidate the role of cardiac function on it. We analyzed the dopaminergic system in the nigrostriatal pathway of Parkinsonian and dyskinetic monkeys and the expression of some key proteins in the metabolism and synthesis of catecholamines in the heart: total and phosphorylated (phospho) tyrosine hydroxylase (TH), and membrane (MB) and soluble

SUBMITTER: Cuenca-Bermejo L 

PROVIDER: S-EPMC8494805 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature