Prednisone-induced sustained remission in a patient with familial fibronectin glomerulopathy (GFND).

ABSTRACT: Glomerulopathy with Fibronectin Deposits (GFND) is a rare, autosomal dominant disease characterized by proteinuria, hematuria and progressive renal failure associated with glomerular deposition of fibronectin, frequently resulting in end-stage renal disease (ESRD). There is no established treatment for this condition beyond conservative measures such as blood pressure control and the use of angiotensin-converting enzyme (ACE) inhibitors. We present a case of GFND associated with progressive chronic kidney disease (CKD) and nephrotic range proteinuria showing a sustained response to prednisone treatment. A 27-year-old G₂P₂ Caucasian female presented with 3 g/day of proteinuria, serum creatinine (Cr) 0.7 mg/dL, inactive urinary sediment and normotension without medicati

SUBMITTER: Goldman BI 

PROVIDER: S-EPMC8494821 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature