AcNASH index to diagnose nonalcoholic steatohepatitis: a prospective derivation and global validation study.

ABSTRACT:

Background

There is an unmet need for non-invasive biomarkers for the diagnosis of nonalcoholic steatohepatitis (NASH) in non-specialized settings. We aimed to develop and validate a non-invasive test for diagnosing NASH in individuals with biopsy-proven nonalcoholic fatty liver disease (NAFLD).

Methods

We developed a non-invasive test named the acNASH index that combines serum creatinine and aspartate aminotransferase levels in a derivation cohort of 390 Chinese NAFLD patients admitted to the hepatology center of the First Affiliated Hospital of Wenzhou Medical University (China) between December 2016 and September 2019 and subsequently validated in five external cohorts of different ethnicities of patients with biopsy-confirmed NAFLD (pooled n=1,089).

Findings

SUBMITTER: Wu XX 

PROVIDER: S-EPMC8495106 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature