Fate of adipocyte progenitors during adipogenesis in mice fed a high-fat diet.

ABSTRACT:

Objective

Expansion of adipose tissue during obesity through the recruitment of newly generated adipocytes (hyperplasia) is metabolically healthy, whereas that through the enlargement of pre-existing adipocytes (hypertrophy) leads to metabolic complications. Accumulating evidence from genetic fate mapping studies suggests that in animal models receiving a high-fat diet (HFD), only adipocyte progenitors (APs) in gonadal white adipose tissue (gWAT) have proliferative potential. However, the proliferative potential and differentiating capacity of APs in the inguinal WAT (iWAT) of male mice remains controversial. The objective of this study was to investigate the proliferative and adipogenic potential of APs in the iWAT of HFD-fed male mice.

Methods

We generated PDGFRα-GFP-Cre-E

SUBMITTER: Bilal M 

PROVIDER: S-EPMC8495176 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature