Exhaled Volatile Organic Compounds for Identifying Patients With Chronic Pulmonary Aspergillosis.

ABSTRACT: Background: Diagnosing chronic pulmonary aspergillosis is a major challenge in clinical practice. The development and validation of a novel, sensitive and specific assay for diagnosing chronic pulmonary aspergillosis is urgently needed. Methods: From April 2018 to June 2019, 53 patients with chronic pulmonary aspergillosis (CPA), 32 patients with community-acquired pneumonia (CAP) and 48 healthy controls were recruited from the First Affiliated Hospital of Guangzhou Medical University. Clinical characteristics and samples were collected at enrollment. All exhaled breath samples were analyzed offline using thermal desorption single-photon ionization time-of-flight mass spectrometry; to analyze the metabolic pathways of the characteristic volatile organic compounds, serum sampl

SUBMITTER: Li ZT 

PROVIDER: S-EPMC8495266 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature