Racial disparity in taxane-induced neutropenia among cancer patients.

ABSTRACT:

Background

Large interindividual variations have been reported in chemotherapy-induced toxicities. Little is known whether racial disparities exist in neutropenia associated with taxanes.

Methods

Patients with a diagnosis of primary cancer who underwent chemotherapy with taxanes were identified from Vanderbilt University Medical Center's Synthetic Derivative. Multinomial regression models were applied to evaluate odds ratios (ORs) and 95% confidence intervals (CIs) of neutropenia associated with race, with adjustments for demographic variables, baseline neutrophil count, chemotherapy-related information, prior treatments, and cancer site.

Results

A total of 3492 patients were included in the study. Compared with White patients, grade 2 or higher neutropenia was more f

SUBMITTER: Zheng NS 

PROVIDER: S-EPMC8495275 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature