A Pan-Cancer Analysis of SLC12A5 Reveals Its Correlations with Tumor Immunity.

ABSTRACT:

Background

Solute carrier family 12 member 5 (SLC12A5) has been reported to play an oncogenic role in certain malignancies. Its prognostic roles and immune mechanisms of action in human cancers, however, remain largely unknown.

Methods

Data derived from TCGA, GEPIA, and TIMER databases were utilized to delve into the expressing patterns, prognostic values, clinical significances, and tumor immunity of SLC12A5 in tumors. Additionally, the association of SLC12A5 expressions with tumor mutation burden (TMB), methyltransferases, and mismatch repairs (MMRs) was also analyzed.

Results

Herein, we observed that SLC12A5 was significantly overexpressed in various malignancies, and SLC12A5 levels correlated with overall survival, disease-specific survival, and tumor stage of cer

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC8495467 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature