Long-term Benefits and Harms Associated With Genetic Cholesteryl Ester Transfer Protein Deficiency in the General Population.

ABSTRACT:

Importance

The balance between the potential long-term clinical benefits and harms associated with genetic cholesteryl ester transfer protein (CETP) deficiency, mimicking pharmacologic CETP inhibition, is unknown.

Objective

To assess the relative benefits and harms associated with genetic CETP deficiency.

Design, setting, and participants

This study examined 2 similar prospective cohorts of the Danish general population, with data on a total of 102 607 participants collected from October 10, 1991, through December 7, 2018.

Exposures

Weighted CETP allele scores.

Main outcomes and measures

Incident cardiovascular mortality, ischemic heart disease, myocardial infarction, ischemic stroke, peripheral arterial disease, vascular dementia, Alzheimer disease, all

SUBMITTER: Nordestgaard LT 

PROVIDER: S-EPMC8495609 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature