Combinatorial effect of radium-223 and irreversible electroporation on prostate cancer bone metastasis in mice.

ABSTRACT:

Background

Metastatic prostate cancer in bone is difficult to treat as the tumor cells are relatively resistant to hormonal or chemotherapies when compared to primary prostate cancer. Irreversible electroporation (IRE) is a minimally invasive ablation procedure that has potential applications in the management of prostate cancer in bone. However, a common limitation of IRE is tumor recurrence, which arises from incomplete ablation that allows remaining cancer cells to proliferate. In this study, we combined IRE with radium-223 (Ra-223), a bone-seeking radionuclide that emits short track length alpha particles and thus is associated with reduced damage to the bone marrow and evaluated the impact of the combination treatment on bone-forming prostate cancer tumors.

Methods

The

SUBMITTER: Rojo RD 

PROVIDER: S-EPMC8495630 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature