Two sequential activation modules control the differentiation of protective T helper-1 (Th1) cells.

ABSTRACT: Interferon-γ (IFN-γ)-producing CD4⁺ T helper-1 (Th1) cells are critical for protection from microbes that infect the phagosomes of myeloid cells. Current understanding of Th1 cell differentiation is based largely on reductionist cell culture experiments. We assessed Th1 cell generation in vivo by studying antigen-specific CD4⁺ T cells during infection with the phagosomal pathogen Salmonella enterica (Se), or influenza A virus (IAV), for which CD4⁺ T cells are less important. Both microbes induced T follicular helper (Tfh) and interleukin-12 (IL-12)-independent Th1 cells. During Se infection, however, the Th1 cells subsequently outgrew the Tfh cells via an IL-12-dependent process and formed subsets with increased IFN-γ production, ZEB2-transcription factor-d

SUBMITTER: Krueger PD 

PROVIDER: S-EPMC8495663 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature