Characterizing preclinical sub-phenotypic models of acute respiratory distress syndrome: An experimental ovine study.

ABSTRACT: The acute respiratory distress syndrome (ARDS) describes a heterogenous population of patients with acute severe respiratory failure. However, contemporary advances have begun to identify distinct sub-phenotypes that exist within its broader envelope. These sub-phenotypes have varied outcomes and respond differently to several previously studied interventions. A more precise understanding of their pathobiology and an ability to prospectively identify them, may allow for the development of precision therapies in ARDS. Historically, animal models have played a key role in translational research, although few studies have so far assessed either the ability of animal models to replicate these sub-phenotypes or investigated the presence of sub-phenotypes within animal models. Here, in three ovi

SUBMITTER: Millar JE 

PROVIDER: S-EPMC8495778 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature