Dataset Information

MoS₂-Embedded, Interpenetrating Network Composite Hydrogels that Show Controlled Release of Dyes and Tunable Strength.

ABSTRACT: This paper describes a conceptual design of hierarchical composite hydrogels. The hydrogel materials comprise MoS₂ flakes and interpenetrating polymer networks, and further exhibit controlled release and tunable strength that are caused by the synergistic combination of select components. In terms of design, MoS₂ flakes initiate radical polymerization of chosen monomers and simultaneously provide physical cross-linking points, both of which afford a primary composite network. Then, the sequential formation of additional networks results in functional, hierarchical, composite hydrogels. Therefore, we were able to demonstrate double-network hydrogels as a stimuli-responsive vector for programmed release of cargo molecules in response to heat or light or to form triple-network hydrogels showing tunable mechanical strength owing to intermolecular interaction between charged monomers and MoS₂ flakes. The design concept would be expanded by incorporating other chalcogenides or functional monomers, which advance the properties and functionalities of materials and broadens the versatility of nanocomposite hydrogels.

SUBMITTER: Lee KM

PROVIDER: S-EPMC8495838 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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MoS2-Embedded, Interpenetrating Network Composite Hydrogels that Show Controlled Release of Dyes and Tunable Strength.

Lee Kyoung Min KM Jeong Songah S Park Jieun J Kim Hyungwoo H

ACS omega 20210924 39

This paper describes a conceptual design of hierarchical composite hydrogels. The hydrogel materials comprise MoS2 flakes and interpenetrating polymer networks, and further exhibit controlled release and tunable strength that are caused by the synergistic combination of select components. In terms of design, MoS2 flakes initiate radical polymerization of chosen monomers and simultaneously provide physical cross-linking points, both of which afford a primary composite networ ...[more]

PMID: 34632218

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Project description:Hydrogels are effective platforms for use as artificial extracellular matrices, cell carriers, and to present bioactive cues. Two common natural polymers, fibrin and alginate, are broadly used to form hydrogels and have numerous advantages over synthetic materials. Fibrin is a provisional matrix containing native adhesion motifs for cell engagement, yet the interplay between mechanical properties, degradation, and gelation rate is difficult to decouple. Conversely, alginate is highly tunable yet bioinert and requires modification to present necessary adhesion ligands. To address these challenges, we developed a fibrin-alginate interpenetrating network (IPN) hydrogel to combine the desirable adhesion and stimulatory characteristics of fibrin with the tunable mechanical properties of alginate. We tested its efficacy by examining capillary network formation with entrapped co-cultures of mesenchymal stromal cells (MSCs) and endothelial cells (ECs). We manipulated thrombin concentration and alginate crosslinking density independently to modulate the fibrin structure, mesh size, degradation, and biomechanical properties of these constructs. In IPNs of lower stiffness, we observed a significant increase in total cell area (1.7 × 105 ± 7.9 × 104 µm2) and decrease in circularity (0.56 ± 0.03) compared to cells encapsulated in stiffer IPNs (4.0 × 104 ± 1.5 × 104 µm2 and 0.77 ± 0.09, respectively). Fibrinogen content did not influence capillary network formation. However, higher fibrinogen content led to greater retention of these networks confirmed via increased spreading and presence of F-actin at 7 days. This is an elegant platform to decouple cell adhesion and hydrogel bulk stiffness that will be broadly useful for cell instruction and delivery. STATEMENT OF SIGNIFICANCE: Hydrogels are widely used as drug and cell delivery vehicles and as artificial extracellular matrices to study cellular responses. However, there are limited opportunities to simultaneously control mechanical properties and degradation while mimicking the complex native adhesion motifs and ligands known to encourage cell engagement with the hydrogel. In this study, we describe a fibrin-alginate interpenetrating network (IPN) hydrogel designed to balance the compliance and provisional qualities of fibrin with the mechanical stability and tunability of alginate to interrogate these contributions on cell response. We used clinically relevant cell sources, a co-culture of endothelial cells and mesenchymal stromal cells, to test its efficacy in supporting capillary formation in vitro. These data demonstrate the promise of this IPN for use in tissue engineering.

Dataset Information

MoS₂-Embedded, Interpenetrating Network Composite Hydrogels that Show Controlled Release of Dyes and Tunable Strength.

Publications

MoS<sub>2</sub>-Embedded, Interpenetrating Network Composite Hydrogels that Show Controlled Release of Dyes and Tunable Strength.

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