Elevated level of the soluble receptor for advanced glycation end-products involved in sarcopenia: an observational study.

ABSTRACT:

Background

The soluble receptor for advanced glycation end products (sRAGE) has been proposed to serve as a marker for disease severity, but its role in sarcopenia, an age-related progressive loss of muscle mass and function, remains elusive. This study examines the association between sRAGE and sarcopenia.

Methods

A total of 314 community-dwelling elderly adults who had their health examination at Tri-Service General Hospital from 2017 to 2019 underwent protein analysis with enzyme-linked immunosorbent assay. The relationship with sarcopenia and its detailed information, including components and diagnosis status, were examined using linear and logistic regressions.

Results

As for sarcopenia components, low muscle mass (β = 162.8, p = 0.012) and strength (β = 181.31,

SUBMITTER: Wu SE 

PROVIDER: S-EPMC8495916 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature