Clinicopathologic significance and prognostic value of circRNAs in osteosarcoma: a systematic review and meta-analysis.

ABSTRACT:

Background

Osteosarcoma is the most prevalent malignant osseous sarcoma in children and adolescents, whose prognosis is still relatively poor nowadays. Recent studies have shown the critical function and potential clinical applications of circular RNAs (circRNAs) in osteosarcoma. Our review aimed to perform an updated meta-analysis to explore their clinicopathologic significance and prognostic value.

Methods

The structured literature was conducted via eight electronic databases and four gray literature sources until 20 Feb 2021 to identify eligible studies. The data was extracted directly from the articles or reconstructed based on Kaplan-Meier curves. The Newcastle-Ottawa Scale (NOS) tool was used to assess study quality. The clinicopathologic significance of circRNAs was m

SUBMITTER: Zhong J 

PROVIDER: S-EPMC8495992 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature