Integrated analysis of lncRNA-miRNA-mRNA ceRNA network in human aortic dissection.

ABSTRACT:

Background

Many studies on long chain non-coding RNAs (lncRNAs) are published in recent years. But the roles of lncRNAs in aortic dissection (AD) are still unclear and should be further examined. The present work focused on determining the molecular mechanisms underlying lncRNAs regulation in aortic dissection on the basis of the lncRNA-miRNA-mRNA competing endogenous RNA (ceRNA) network.

Methods

This study collected the lncRNAs (GSE52093), mRNAs (GSE52093) and miRNAs (GSE92427) expression data within human tissue samples with aortic dissection group and normal group based on Gene Expression Omnibus (GEO) database.

Results

This study identified three differentially expressed lncRNAs (DELs), 19 differentially expressed miRNAs (DEmiRs) and 1046 differentially expressed

SUBMITTER: Zhang H 

PROVIDER: S-EPMC8495997 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature