Global properties of regulatory sequences are predicted by transcription factor recognition mechanisms.

ABSTRACT:

Background

Mammalian genomes contain millions of putative regulatory sequences, which are delineated by binding of multiple transcription factors. The degree to which spacing and orientation constraints among transcription factor binding sites contribute to the recognition and identity of regulatory sequence is an unresolved but important question that impacts our understanding of genome function and evolution. Global mechanisms that underlie phenomena including the size of regulatory sequences, their uniqueness, and their evolutionary turnover remain poorly described.

Results

Here, we ask whether models incorporating different degrees of spacing and orientation constraints among transcription factor binding sites are broadly consistent with several global properties of regu

SUBMITTER: Patel ZM 

PROVIDER: S-EPMC8496038 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature