Minimally important differences for the EORTC QLQ-C30 in prostate cancer clinical trials.

ABSTRACT:

Background

The aim of the study was to estimate the minimally important difference (MID) for interpreting group-level change over time, both within a group and between groups, for the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) scores in patients with prostate cancer.

Methods

We used data from two published EORTC trials. Clinical anchors were selected by strength of correlations with QLQ-C30 scales. In addition, clinicians' input was obtained with regard to plausibility of the selected anchors. The mean change method was applied for interpreting change over time within a group of patients and linear regression models were fitted to estimate MIDs for between-group differences in change over time. Distributio

SUBMITTER: Gamper EM 

PROVIDER: S-EPMC8496068 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature