Targeting the RNA demethylase FTO for cancer therapy.

ABSTRACT: N ⁶-Methyladenosine (m⁶A) is the most prevalent internal modification on mRNA and represents a new layer of gene expression in eukaryotes. The field of m⁶A-encoded epitranscriptomics was rejuvenated with the discovery of fat mass and obesity-associated protein (FTO) as the first m⁶A demethylase responsible for RNA modification in cells. Increasing evidence has revealed that FTO is significantly involved in physiological processes, and its dysregulation is implicated in various human diseases. Considering this functional significance, developing small-molecule modulators of the FTO protein represents a novel direction for biology research. However, such modulators remain in the early stages of development. Here, our review mainly focuses on

SUBMITTER: Zhou LL 

PROVIDER: S-EPMC8496078 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature