Genetic and epigenetic associations of ANRIL with coronary artery disease and risk factors.

ABSTRACT:

Background

Both DNA genotype and methylation of antisense non-coding RNA in the INK4 locus (ANRIL) have been robustly associated with coronary artery disease (CAD), but the interdependent mechanisms of genotype and methylation remain unclear.

Methods

Eighteen tag single nucleotide polymorphisms (SNPs) of ANRIL were genotyped in a matched case-control study (cases 503 and controls 503). DNA methylation of ANRIL and the INK4/ARF locus (p14^ARF, p15^INK4b and p16^INK4a) was measured using pyrosequencing in the same set of samples (cases 100 and controls 100).

Results

Polymorphisms of ANRIL (rs1004638, rs1333048 and rs1333050) were significantly associated with CAD (p < 0.05). The incidence of CAD, multi-vessel disease, and modified Gensini s

SUBMITTER: Xu B 

PROVIDER: S-EPMC8496081 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature