Chromogranin A demonstrates higher expression in preeclamptic placentas than in normal pregnancy.

ABSTRACT:

Background

Although preeclampsia has long been recognized as a condition affecting late pregnancy, little is known of its pathogenesis or treatment. The placenta releases a number of hormones and molecules that influence the course of pregnancy, one of which is chromogranin A, a soluble protein secreted mainly from the chromaffin cells of the adrenal medulla. Its role in pregnancy and pregnancy-related disorders remains unclear. Therefore, the main aim of the proposed study is to determine whether chromogranin A is related with the occurrence of preeclampsia.

Methods

Placental samples were collected from 102 preeclamptic patients and 103 healthy controls, and Chromogranin A gene (CHGA) expression was measured using real-time RT-PCR, The RT-PCR results were verified on the pr

SUBMITTER: Bralewska M 

PROVIDER: S-EPMC8496087 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature