MicroRNA-Dependent Control of Sensory Neuron Function Regulates Posture Behavior in Drosophila.

ABSTRACT: All what we see, touch, hear, taste, or smell must first be detected by the sensory elements of our nervous system. Sensory neurons, therefore, represent a critical component in all neural circuits and their correct function is essential for the generation of behavior and adaptation to the environment. Here, we report that the evolutionarily-conserved microRNA (miRNA) miR-263b plays a key behavioral role in Drosophila melanogaster through effects on the function of larval sensory neurons. Several independent experiments (in 50:50 male:female populations) support this finding: first, miRNA expression analysis, via reporter expression and fluorescent-activated cell sorting (FACS)-quantitative PCR (qPCR) analysis, demonstrate miR-263b expression in larval sensory neurons.

SUBMITTER: Klann M 

PROVIDER: S-EPMC8496190 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature