CRISPR-mediated knock-in of transgenes into the malaria vector Anopheles funestus.

ABSTRACT: The ability to introduce mutations, or transgenes, of choice to precise genomic locations has revolutionized our ability to understand how genes and organisms work. In many mosquito species that are vectors of various human diseases, the advent of CRISPR genome editing tools has shed light on basic aspects of their biology that are relevant to their efficiency as disease vectors. This allows a better understanding of how current control tools work and opens up the possibility of novel genetic control approaches, such as gene drives, that deliberately introduce genetic traits into populations. Yet for the Anopheles funestus mosquito, a significant vector of malaria in sub-Saharan Africa and indeed the dominant vector species in many countries, transgenesis has yet to be achieved. We describ

SUBMITTER: Quinn C 

PROVIDER: S-EPMC8496255 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature