Dissection of quantitative trait loci in the Lachancea waltii yeast species highlights major hotspots.

ABSTRACT: Dissecting the genetic basis of complex trait remains a real challenge. The budding yeast Saccharomyces cerevisiae has become a model organism for studying quantitative traits, successfully increasing our knowledge in many aspects. However, the exploration of the genotype-phenotype relationship in non-model yeast species could provide a deeper insight into the genetic basis of complex traits. Here, we have studied this relationship in the Lachancea waltii species which diverged from the S. cerevisiae lineage prior to the whole-genome duplication. By performing linkage mapping analyses in this species, we identified 86 quantitative trait loci (QTL) impacting the growth in a large number of conditions. The distribution of these loci across the genome has revealed two major QTL hotspots. A fi

SUBMITTER: Peltier E 

PROVIDER: S-EPMC8496267 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature