Normal Tissue Injury Induced by Photon and Proton Therapies: Gaps and Opportunities.

ABSTRACT: Despite technological advances in radiation therapy (RT) and cancer treatment, patients still experience adverse effects. Proton therapy (PT) has emerged as a valuable RT modality that can improve treatment outcomes. Normal tissue injury is an important determinant of the outcome; therefore, for this review, we analyzed 2 databases: (1) clinical trials registered with ClinicalTrials.gov and (2) the literature on PT in PubMed, which shows a steady increase in the number of publications. Most studies in PT registered with ClinicalTrials.gov with results available are nonrandomized early phase studies with a relatively small number of patients enrolled. From the larger database of nonrandomized trials, we listed adverse events in specific organs/sites among patients with cancer who are treate

SUBMITTER: Prasanna PG 

PROVIDER: S-EPMC8496269 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature