Evidence for a force favoring GC over AT at short intronic sites in Drosophila simulans and Drosophila melanogaster.

ABSTRACT: Population genetics studies often make use of a class of nucleotide site free from selective pressures, in order to make inferences about population size changes or natural selection at other sites. If such neutral sites can be identified, they offer the opportunity to avoid any confounding effects of selection. Here, we investigate evolution at putatively neutrally evolving short intronic sites in natural populations of Drosophila melanogaster and Drosophila simulans, in order to understand the properties of spontaneous mutations and the extent of GC-biased gene conversion in these species. Use of data on the genetics of natural populations is advantageous because it integrates information from large numbers of individuals over long timescales. In agreement with direct evidence from obser

SUBMITTER: Jackson B 

PROVIDER: S-EPMC8496279 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature