Human MAIT cells are devoid of alloreactive potential: prompting their use as universal cells for adoptive immune therapy.

ABSTRACT:

Background

Mucosal-associated invariant T (MAIT) cells are semi-invariant T cells that recognize microbial antigens presented by the highly conserved MR1 molecule. MAIT cells are predominantly localized in the liver and barrier tissues and are potent effectors of antimicrobial defense. MAIT cells are very few at birth and accumulate gradually over a period of about 6 years during the infancy. The cytotoxic potential of MAIT cells, as well as their newly described regulatory and tissue repair functions, open the possibility of exploiting their properties in adoptive therapy. A prerequisite for their use as 'universal' cells would be a lack of alloreactive potential, which remains to be demonstrated.

Methods

We used ex vivo, in vitro and in vivo models to determine if human MA

SUBMITTER: Tourret M 

PROVIDER: S-EPMC8496386 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature