A Novel H₂O₂ Generator for Tumor Chemotherapy-Enhanced CO Gas Therapy.

ABSTRACT: Carbon monoxide (CO) gas therapy is a promising cancer treatment. However, gas delivery to the tumor site remains problematic. Proper tunable control of CO release in tumors is crucial to increasing the efficiency of CO treatment and reducing the risk of CO poisoning. To overcome such challenges, we designed ZCM, a novel stable nanotechnology delivery system comprising manganese carbonyl (MnCO) combined with anticancer drug camptothecin (CPT) loaded onto a zeolitic imidazole framework-8 (ZIF-8). After intravenous injection, ZCM gradually accumulates in cancerous tissues, decomposing in the acidic tumor microenvironment, releasing CPT and MnCO. CPT acts as a chemotherapy agent destroying tumors and producing copious H₂O₂. MnCO can react with the H₂O₂

SUBMITTER: Li Y 

PROVIDER: S-EPMC8496405 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature