Ocular Penetrance and Safety of the Dopaminergic Prodrug Etilevodopa.

ABSTRACT:

Purpose

Animal models have demonstrated the role of dopamine in regulating axial elongation, the critical feature of myopia. Because frequent delivery of dopaminergic agents via peribulbar, intravitreal, or intraperitoneal injections is not clinically viable, we sought to evaluate ocular penetration and safety of the topically applied dopaminergic prodrug etilevodopa.

Methods

The ocular penetration of dopamine and dopaminergic prodrugs (levodopa and etilevodopa) were quantified using an enzyme-linked immunosorbent assay in enucleated porcine eyes after a single topical administration. The pharmacokinetic profile of the etilevodopa was then assessed in rats. A four-week once-daily application of etilevodopa as a topical eye drop was conducted to establish its safety profile.<

SUBMITTER: Gao Q 

PROVIDER: S-EPMC8496415 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature