Conditional and biased regeneration of cone photoreceptor types in the zebrafish retina.

ABSTRACT: A major challenge in regenerative medicine is replacing cells lost through injury or disease. While significant progress has been made, much remains unknown about the accuracy of native regenerative programs in cell replacement. Here, we capitalized on the regenerative capacity and stereotypic retinal organization of zebrafish to determine the specificity with which retinal Müller glial cells replace lost neuronal cell types. By utilizing a targeted genetic ablation technique, we restricted death to all or to distinct cone photoreceptor types (red, blue, or UV-sensitive cones), enabling us to compare the composition of cones that are regenerated. We found that Müller glia produce cones of all types upon nondiscriminate ablation of these photoreceptors, or upon selective ablation of red or

SUBMITTER: D'Orazi FD 

PROVIDER: S-EPMC8496684 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature