Fracture biomechanics influence local and systemic immune responses in a murine fracture-related infection model.

ABSTRACT: Biomechanical stability plays an important role in fracture healing, with unstable fixation being associated with healing disturbances. A lack of stability is also considered a risk factor for fracture-related infection (FRI), although confirmatory studies and an understanding of the underlying mechanisms are lacking. In the present study, we investigate whether biomechanical (in)stability can lead to altered immune responses in mice under sterile or experimentally inoculated conditions. In non-inoculated C57BL/6 mice, instability resulted in an early increase of inflammatory markers such as granulocyte-colony stimulating factor (G-CSF), keratinocyte chemoattractant (KC) and interleukin (IL)-6 within the bone. When inoculated with Staphylococcus epidermidis, instability resulted in a furth

SUBMITTER: Sabate-Bresco M 

PROVIDER: S-EPMC8496694 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature