Ontology highlight
ABSTRACT:
SUBMITTER: Brinck Andersen NS
PROVIDER: S-EPMC8496727 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Brinck Andersen Nanna-Sophie NS Jørgensen Sofie Eg SE Skipper Kristian Alsbjerg KA Larsen Simon Müller SM Heinz Johanna J Thomsen Michelle Mølgaard MM Farahani Ensieh E Cai Yujia Y Hait Alon Schneider AS Kay Lise L Giehm Mikkelsen Jacob J Høgsbjerg Schleimann Mariane M Thomsen Martin Kristian MK Paludan Søren R SR Mogensen Trine H TH
Autophagy 20201020 9
Paralytic poliomyelitis is a rare disease manifestation following poliovirus (PV) infection. The disease determinants remain largely unknown. We used whole exome sequencing to uncover possible contributions of host genetics to the development of disease outcome in humans with poliomyelitis. We identified a patient with a variant in <i>ATG7</i>, an important regulatory gene in the macroautophagy/autophagy pathway. PV infection did not induce a prominent type I interferon response, but rather acti ...[more]