HSP105 expression in cutaneous malignant melanoma: Correlation with clinicopathological characteristics.

ABSTRACT:

Background

Heat shock proteins can protect against stress-associated cellular challenges, but they can also protect some tumors from human immune system monitoring. Heat shock protein 105 (HSP105/110) is a high molecular weight protein whose expression has been reported in many cancers, but few studies on its role in cutaneous malignant melanoma have been published. In this study, we analyzed the relationship between HSP105 expression and the clinicopathological characteristics of CMM.

Methods

This retrospective study included 91 patients with CMM. The clinicopathological characteristics of CMM patients, including age, lesion duration, location, pathological classification, Clark's level, Breslow thickness, metastasis and recurrence, were collected. Immunohistochemical stain

SUBMITTER: Chen KJ 

PROVIDER: S-EPMC8496777 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature