The blood metabolome of incident kidney cancer: A case-control study nested within the MetKid consortium.

ABSTRACT:

Background

Excess bodyweight and related metabolic perturbations have been implicated in kidney cancer aetiology, but the specific molecular mechanisms underlying these relationships are poorly understood. In this study, we sought to identify circulating metabolites that predispose kidney cancer and to evaluate the extent to which they are influenced by body mass index (BMI).

Methods and findings

We assessed the association between circulating levels of 1,416 metabolites and incident kidney cancer using pre-diagnostic blood samples from up to 1,305 kidney cancer case-control pairs from 5 prospective cohort studies. Cases were diagnosed on average 8 years after blood collection. We found 25 metabolites robustly associated with kidney cancer risk. In particular, 14 glycerophos

SUBMITTER: Guida F 

PROVIDER: S-EPMC8496779 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature