Association Between Childhood Green Space, Genetic Liability, and the Incidence of Schizophrenia.

ABSTRACT: Childhood exposure to green space has previously been associated with lower risk of developing schizophrenia later in life. It is unclear whether this association is mediated by genetic liability or whether the 2 risk factors work additively. Here, we investigate possible gene-environment associations with the hazard ratio (HR) of schizophrenia by combining (1) an estimate of childhood exposure to residential-level green space based on the normalized difference vegetation index (NDVI) from Landsat satellite images, with (2) genetic liability estimates based on polygenic risk scores for 19 746 genotyped individuals from the Danish iPSYCH sample. We used information from the Danish registers of health, residential address, and socioeconomic status to adjust HR estimates for established confo

SUBMITTER: Engemann K 

PROVIDER: S-EPMC8496913 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature