Novel insights in cell cycle dysregulation during prostate cancer progression.

ABSTRACT: Prostate cancer (CaP) remains the second leading cause of cancer deaths in Western men. These deaths occur because metastatic CaP acquires resistance to available treatments. The novel and functionally diverse treatment options that have been introduced in the clinic over the past decade each eventually induce resistance for which the molecular basis is diverse. Both initiation and progression of CaP have been associated with enhanced cell proliferation and cell cycle dysregulation. A better understanding of the specific pro-proliferative molecular shifts that control cell division and proliferation during CaP progression may ultimately overcome treatment resistance. Here, we examine literature for support of this possibility. We start by reviewing recently renewed insights in prostate cel

SUBMITTER: Ben-Salem S 

PROVIDER: S-EPMC8496945 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature