Impact of early life geohelminths on wheeze, asthma and atopy in Ecuadorian children at 8 years.

ABSTRACT:

Background

Early-life exposures to geohelminths may protect against development of wheeze/asthma and atopy.

Objective

To study the effect of maternal geohelminths and infections in children during the first 5 years on atopy, wheeze/asthma and airways reactivity/inflammation at 8 years.

Methods

Birth cohort of 2404 neonates followed to 8 years in rural Ecuador. Data on wheeze/asthma were collected by questionnaire and atopy by skin prick test (SPT) reactivity to 9 allergens. We measured airways reactivity to bronchodilator, fractional exhaled nitric oxide (FeNO) and nasal eosinophilia. Stool samples were examined for geohelminths by microscopy.

Results

1933 (80.4%) children were evaluated at 8 years. Geohelminths were detected in 45.8% of mothers and 45.5% of ch

SUBMITTER: Cooper PJ 

PROVIDER: S-EPMC8496980 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature